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Individuals who have been infected by varicella-zoster virus may develop (Kaposi's sarcoma/shingles/whitlows)later in life if they experience severe stress or immune suppression.

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Which of the following statements regarding the association of hepatitis B with liver cancer is FALSE?


A) Geographic areas with a high incidence of liver cancer also have a high prevalence of hepatitis B.
B) The HBV genome has been found integrated into hepatic cancer cells.
C) Hepatic cancer cells typically express HBV antigen.
D) Chronic carriers of the virus are 200 times more likely to develop hepatic cancer.
E) Vaccination does not provide protection against the development of hepatic cancer.

F) C) and E)
G) None of the above

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What conditions may trigger reactivation of latent herpesvirus infections?


A) co-infection with hepatitis D virus
B) major hormonal changes
C) immune suppression
D) co-infection with hepatitis D virus along with hormonal changes
E) immune suppression or hormonal changes can both trigger reactivation

F) B) and E)
G) B) and C)

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The ________ primarily infects lymphocytes.


A) BK virus
B) Adenovirus
C) B19 virus
D) HHV-6
E) HHV-8

F) A) and B)
G) A) and C)

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Reactivation of ________ in immunosuppressed persons may produce Kaposi's sarcoma,a cancer of the blood vessels.


A) EBV
B) HHV-6
C) cytomegalovirus
D) HHV-8
E) BK virus

F) All of the above
G) B) and E)

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Which of the following viruses is responsible for erythema infectiosum?


A) adenoviruses
B) human herpesvirus 1
C) varicella
D) human herpesvirus 4
E) B19 virus

F) All of the above
G) None of the above

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The first documented human disease to be eradicated was smallpox.

A) True
B) False

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What makes neonatal herpes a very serious condition?


A) The potential for life-long infection.
B) Central nervous system infection of the neonate.
C) HHV infection of the bone marrow.
D) Development of lymphoma.
E) The potential for oncogenesis.

F) A) and B)
G) A) and C)

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Characteristic features of the herpesvirus used for diagnosis include the


A) presence of recurring lesions in the lip or genital regions.
B) presence of syncytia in infected tissue.
C) presence of recurring lesions in the lip or genital regions and syncytia in infected tissue.
D) ability of the virus to be transmitted to neonates.
E) presence of viruses intracellularly years after recovery from the infection.

F) D) and E)
G) C) and E)

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Compare and contrast the oncogenic viruses human herpesvirus 4 (Epstein-Barr virus)and hepatitis B virus (HBV).

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HHV-4 infects B-lymphocytes and is prima...

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A childhood illness caused by a herpesvirus and characterized by a "rosy" rash all over the body is known as


A) chickenpox.
B) kissing disease.
C) CMV.
D) monkeypox.
E) roseola.

F) B) and C)
G) None of the above

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The condition in which athletes develop herpes lesions on their skin as a result of coming in contact with herpes lesions during wrestling is known as herpes (gladiatorum/whitlow/zoster).

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The common name for the disease caused by human parvovirus B19 is


A) kissing disease.
B) fourth disease.
C) fifth disease.
D) shingles.
E) Reyes' syndrome.

F) B) and E)
G) A) and C)

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Papillomaviruses are transmitted by (aerosols/direct contact/secretions).

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Hepatitis B virus replicates in liver cells and is released by (extrusion/exocytosis/lysis),which contributes to the infection becoming chronic.

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